From Interstate 275 (I-275): 1. **Exit I-275 At Exit 40B** For North Lois Avenue Toward International Plaza. 2. **Turn North Onto North Lois Avenue** And Continue For Approximately 0.5 Miles. 3. **Turn Left Onto West Spruce Street** And Proceed For About 0.2 Miles. 4. **Arrive At 4221 W Spruce Street**, Which Will Be On Your Right. This Route Takes You Directly From I-275 To Your Destination Via North Lois Avenue And West Spruce Street.